Mark Schofield

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Mark Schofield

Research Professor of Chemistry


Office Phone: (202) 994-6121
800 22nd St. NW Washington DC 20052


“Sophorolipid Analog Compositions” Mark H. Schofield, Richard

A. Gross, US Patent No. 8685942 Issued April 1, 2014 “Modified Sophorolipids for the Inhibition of Plant Pathogens” Mark H. Schofield, Thavasi Renga Thavasi, Richard A. Gross, International US Patent No. 085067 Issued April 4, 2013.


Inorganic Synthesis, Homogenous Catalysis, Electronic Structure Calculations, Biomaterials.

Inorganic chemistry writ large contributes to materials science, biochemistry, homogeneous catalysis, and medicinal chemistry, among other areas. Using this eclectic mix of structure and reactivity, we combine these tools to develop and evaluate the efficacy of novel platinum anti-cancer drugs, fabricate novel biopolymers from fermentation products, and develop, using density functional theory, quantitative measures to evaluate covalency in metal organic frameworks.

My research interests span physical inorganic and organic chemistry, organometallic chemistry and catalysis, and the design of chiral platinum complexes as potential anti-cancer drugs. In addition to mastering inorganic synthesis, students in my lab have developed skills in biochemistry, cell culture, biochemical assays multinuclear NMR, EPR, and other biophysical techniques. I also have a longstanding interest in electronic structure and bonding and have several ongoing projects in molecular modeling using ab initio (via Gaussian 16, ORCA, and NWChem) methods.

Surbella, R. G., III; Ducati, L. C.; Schofield, M. H.; McNamara, B. K.; Pellegrini, K. L.; Corbey, J. F.; Schwantes, J. M.; Autschbach, J.; Cahill, C. L. Plutonium Hybrid Materials: A Platform to Explore Assembly and Metal–Ligand Bonding. Inorg. Chem. 202361, 17963-17971.

Byrne, N. M., Schofield, M. H.; Cahill, C. L. A novel symmetric pyrizine (pyz)-bridged uranyl dimer [UO2Cl3(H2O)(Pyz)0.5]2−: synthesis, structure, and computational analysis. Dalton

Trans.202251, 11013-11020.

Byrne, N. M.; Schofield, M. H.; Nicholas, A. D.; Cahill, C. L. Bimetallic uranyl/cobalt(ii) isothiocyanates: structure, property and spectroscopic analysis of homo- and heterometallic phases. Dalton Trans.202150, 9158-9172.

Brager, D. M.; Nicholas, A. D.; Schofield, M. H.; Cahill C. L., Pb–Oxo Interactions in Uranyl Hybrid Materials: A Combined Experimental and Computational Analysis of Bonding and Spectroscopic Properties. Inorg. Chem. 202160, 17186-17200.

Carter, K. P.; Kalaj, M.; McNeil, S.; Kerridge, A.; Schofield, M. H.; Ridenour, J. A.; Cahill, C. L. Structural, spectroscopic and computational evaluations of cation-cation and halogen bonding interactions in heterometallic uranyl hybrid materials. Inorg. Chem. Front. 20218, 1128-1141.

Morton, J. G.; Joe, C. L.; Stolla, M. C.; Koshland, S. R., Londergan, C. H.; Schofield, M. H.* NMR Determination of Hydrogen Bond Thermodynamics in a Simple Diamide: A Physical Chemistry Experiment. J. Chem. Educ. 2015, 92, 1086-1090.

Viswanathan, K; Schofield, M. H.*; Li, G.; Teraoka, I.; Gross, R. A.* Protease catalyzed synthesis of Phytochelatin mimic: Glutamic acid / Cysteine ethyl ester co-oligomerization and investigation of their metal binding properties. Green Chem. 2012, 14, 1020.

Markgraf, J. H.; Hong, L.; Richardson, D. P.; Schofield, M. H.* Substituent effects on N-15 and C-13 chemical shifts of 5-phenyl- 1,3,4-oxathiazol-2-ones: a theoretical and spectroscopic study. Magn. Reson. Chem. 2007, 45, 985.

Schofield, M. H.*; Halpern, J., Kinetics and mechanism of decomposition of nickel benzyl complexes and determination of nickel-benzyl bond dissociation energies. Inorg. Chim. Acta 2003, 345, 353-358.

Schofield, M. H.; Schrock, R. R.*; Park, L. Y., Rhenium(VII) monoimido alkylidene complexes: synthesis, structure, and Lewis- acid-cocatalyzed olefin metathesis. Organometallics 1991, 10, 1844-51

Schofield, M. H.; Kee, T. P.; Anhaus, J. T.; Schrock, R. R.*; Johnson, K. H.; Davis, W. M., Osmium imido complexes: synthesis, reactivity, and SCF-X -SW electronic structure. Inorg. Chem. 1991, 30, 3595-604.


BS, University of Massachusetts, 1985

PhD, Massachusetts Institute of Technology, 1991 Post-doctoral: University of Chicago 1995